Mutation- Substitution
Main Ideas:
- An exchange between base pairs
- Could affect the codon reading for amino acids
Process:
- When one or multiple base pairs are taken out and are replaced by a different set of base pairs
Example:
- Sickle Cell Anaemia
- GAG is mutated to GTG
- This caused the codon reading to change from glutamate to valine
Reflection Summary:
I really enjoyed learning this topic. Substitution is just one of the types of mutations that we learned about. Most of the information that I received was from class but I did do more research to further my knowledge. One of the things I learned while researching was silent mutations. Silent Mutations are substitutions that don’t effect the protein structure. I always thought that mutation would have an affect but silent mutations don’t.
Citations:
"What Types Of Mutation Are There?". Yourgenome.org. N.p., 2016. Web. 27 Nov. 2016.
"Types Of Mutations: Substitution, Insertions, Deletion And Frameshifts". Biotechnologyforums.com. N.p., 2016. Web. 27 Nov. 2016.
"Protein Synthesis - Notes". Biology | Mrs. McComas. N.p., 2016. Web. 27 Nov. 2016.
What are some of the other diseases caused by substitution? Is the mutation as severe as addition or deletion?
ReplyDeleteSome other diseases are Cystic Fibrosis and Color Blindness.
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ReplyDeleteI really liked your post and I was wondering if there is any certain base pairs that are more likely to be replaced?
ReplyDeleteI really liked your post and I was wondering if there is any certain base pairs that are more likely to be replaced?
ReplyDeleteHow can substitution affect someone long term?
ReplyDeleteA substitution mutation changes one or multiple base pairs which can cause a new amino acid to be made. Genetic diseases are common when a mutation occurs. The most detrimental long term effect would be cancer.
DeleteHow many genes can be affected by substitution, in a single strand?
ReplyDelete